ESR1 and neoplasm: The similar levels of ERα36 in UM-SCC-11A and UM-SCC-12 cells suggest that the increased aggression observed in shESR1-UM-SCC-12 cells was due to a reduction in ERα66 expression, but further studies are needed to determine which isoform(s) of ERα are involved in ERα-silencing induced increases in tumor aggression.