The ChREBP/MLX heterodimer controls glucose and lipid metabolism via regulating the expression of glycolytic (Pklr, Fk, Glut2, Glut4), gluconeogenic (G6pc), and lipogenic (Fasn, Acc1, Scd1, Elovl6) genes1,4,10, suggesting that ChREBP may have an important role in the pathogenesis of metabolic diseases and cancer. Here, MLXIPL is linked to Other metabolic disease.