For example, the formation of pyogenic abscesses was prominent only in Ccn1ΔMyeloid mice but not in Ccn1D125A/D125A mice, suggesting that myeloid cells-derived CCN1 may have negative effects on abscess formation through αv-independent pathways, possibly by regulating bacterial proteins important for abscess formation such as coagulase (Coa) and vWbp66,67. This evidence concerns the gene CCN1 and abscess.