Since glutamate is the endogenous inhibitor of xCT (refs. 44,45), and higher serum concentrations of glutamate have been observed in Parkinson’s disease patients46, our findings further speculate that DJ-1 mutant neuronal cells experience high levels of ferroptosis, which might establish a potential mechanism via which DJ-1 could regulate early-onset recessive Parkinson’s disease. This evidence concerns the gene SLC7A11 and Parkinson disease.