SLC7A11 and Parkinson disease: SMR applied to this locus identified a significant association (Bonferroni-adjusted significance threshold correcting for 12 tests = 4.2 × 10−03) between cg06690548 hypermethylation and downregulation of the neighboring gene SLC7A11 (SMR: p = 3.59 × 10−03, Fig. 3 and Supplementary Table 3), but there was no evidence for a genetic association between PD and either cg06690548 methylation or SLC7A11 expression (i.e., there was no evidence that the association of cg06690548 hypermethylation with PD was owing to genetic factors that influence cg06690548 methylation or SLC7A11 expression).