In our analysis of blood-based DNA methylation in 1132 PD cases and 999 controls, we identified two DNA methylation probes associated with PD using MOA: cg26033520 on chromosome 10 in the vicinity of the ASCC1 (Activating Signal Co-integrator 1 Complex subunit 1) gene and cg06690548 on chromosome 4 in the promoter of the SLC7A11 (Solute Carrier Family 7 member 11) gene. Here, ASCC1 is linked to Parkinson disease.