In the MOA analysis, we identified two epigenome-wide significant associations with PD (Bonferroni-adjusted significance threshold, p < 1.9  ×  10−07; Fig. 2; Table 1), the strongest of which was for cg16001422 on chromosome 8 (p = 2.3  ×  10−08, PLEC gene; Supplementary Fig. 6; Supplementary Data 1). This evidence concerns the gene PLEC and Parkinson disease.