NOD2 and hepatocellular carcinoma: Our data showed that exogenous overexpression of NOD2 could significantly increase the chemosensitivity of HCC cells to sorafenib (Fig. 5a), lenvatinib (Fig. 5d), and 5-FU treatment (Fig. 5g), and further investigation showed NOD2 significantly promoted the therapeutic effect of sorafenib (Fig. 5b), lenvatinib (Fig. 5e) and 5-FU (Fig. 5h) on HCC cells.