The 17 genes in the selected optimal set reflect the tradeoff between aneuploidy and MSI in gastrointestinal and endometrial cancers (Fig. 4a, b), and are strongly enriched in mismatch repair and double strand break repair genes (MLH1, MSH2, PMS2, DNA2, FBXO18, RAD21, and RPA1). Here, RPA1 is linked to endometrial cancer.