POLE3 and neoplasm: Together with the inclusion of several other chromatin remodeling-associated genes in the repair set (POLE3, EPC2, BRCC3, HMGA1, and HMGB1) and the MSI-aneuploidy set (EP300, CUL4B, RPA1, ARID1A, and NFATC4), this could suggest that inhibition of chromatin relaxation resulting from impairing mutations in DNA repair genes prevents the emergence of aneuploidy in tumor cells.