In addition, restoration experiments showed that HOTAIR overexpression abrogated the effects of miR-93 on cell survival, viability, apoptosis, and autophagy in IR-treated CRC cells, suggesting that HOTAIR overexpression weakened radiosensitivity of CRC cells by downregulating miR-93 and relieving miR-93-mediated autophagy inhibition. Here, HOTAIR is linked to colorectal carcinoma.