EP300 and hepatocellular carcinoma: Meanwhile, P300highaPKC-ιhigh HCC patients and patients with overexpression of only P300 or aPKC-ι (P300highaPKC-ιlow + P300lowaPKC-ιhigh) had a much shorter overall survival (OS) than that of P300lowaPKC-ιlow HCC patients (Fig. 1g, Supplementary Table 3).