For patients with mPCa, the incidence of inherited DNA-repair gene mutations was significantly higher than that in localized PCa, and the variants in DNA-repair associated genes such as BRCA1, BRCA2, ATM, CHEK2, RAD51D and PALB2 were involved in the process of PCa metastasis [39]. This evidence concerns the gene CHEK2 and posterior cortical atrophy.