They found that the increased expression of TMPRSS2 was associated with PCa risk and many genes showed the pattern for allele-specific transcriptional activation by PCa-associated regulators such as AR. Since the metabolite profiling is now widely used in screening biomarkers for cancer prediction, Kelly et al. [52] reviewed the metabolic biomarkers identified for PCa diagnosis, prognosis and treatment. This evidence concerns the gene TMPRSS2 and posterior cortical atrophy.