Since that smoking might interact with rs12982687 of UCA1 to induce CRC risk (Additional file 1: Figure S1, Additional file 4: Table S3), there was a possibility that rs12982687 might influence HIF-1 signaling by disturbing binding of UCA1 to miR-873-5p, miR-1207-5p and miR-584. Here, HIF1A is linked to colorectal carcinoma.