In consistence with our previous findings, the results showed that ATP6AP2 expression is higher in tumor tissues than that in normal tissues, moreover, level of ATP6AP2 transcripts in COAD is positively correlated with those of LRP6, CTNNB1, MYC, CCND1 and AXIN2 (Fig. 4c). The gene discussed is ATP6AP2; the disease is colon adenocarcinoma.