APC and colorectal carcinoma: Notably, Wang et al. [10] found that (P) RR silencing markedly inhibited the proliferation and induced the apoptosis of CRC cell lines carrying both activating mutations in Wnt signaling components and KRAS mutations DLD-1 (with APC and KRAS mutations) and HCT116 (with β-catenin and KRAS mutations) by weakening Wnt signaling activity.