Consistent with these findings, Juillerat-Jeanneret et al. [38] also reported a high expression level of (P) RR in human glioblastoma (GBM) (WHO grade IV), the most malignant type of glioma [39], and indicated that attenuation of renin activity in glioblastoma cells could decrease cell proliferation and induce apoptosis. Here, REN is linked to glioblastoma.