KRT20 and colorectal carcinoma: Furthermore, KYA1797K effectively suppressed the expressions of CSC markers with decreased levels of β-catenin and RAS (Fig. 5e, f), while it significantly increased the expression of CK20, a convincing differentiation marker, in PDTX tissues (Additional file 1: Figure S7), suggesting that KYA1797K suppresses the stemness of CRC stem cells.