EGF and neoplasm: Furthermore, the growth of tumor organoids derived from small intestinal tumor cells of ApcMin/+/KrasG12DLA2 mice was effectively suppressed by KYA1797K treatment (Fig. 3e, f) along with significant decreases in the number and size of the tumor organoids at day 7 in the presence of EGF, R-spondin1, and Noggin, mimicking the in vivo condition of hyper-activated CSCs.