APC and colorectal carcinoma: Given that CSC-like populations of CRC cells have elevated protein levels of β-catenin and RAS, compared with non-CSC populations, we investigated whether the stem cell characteristics of CRC are associated with stabilization of β-catenin and RAS by treating the β-catenin and RAS destabilizing compound, KYA1797K [19], on the spheroid-cultured DLD-KRAS-MT CRC cells harboring both APC and KRAS mutations [16, 20].