We employed multiple immunofluorescent labeling of cellular components in tissue sections of the human AITL and Hodgkin lymphoma and found that PD-1 and PD-L1 are localized in different cells, which implies that PD-1+ and PD-L1+ cells both in AITL and in Hodgkin lymphoma belong to two different cell lineages. The gene discussed is CD274; the disease is Hodgkins lymphoma.