We found that clozapine combining with PQQ treatments could ameliorate the memory deficits in MK-801 induced schizophrenia rats partially by reducing the expression of NMDAR1 and MGLUR3, decreasing hippocampal tau hyperphosphorylation and inhibiting apoptosis through GSK-3β/Akt signaling pathway. This evidence concerns the gene AKT1 and schizophrenia.