For instance, in human primary tumors, high expression of Transcription Factor AP-2 Gamma (TFAP2C), a TF found to be amplified in 6% of primary breast cancers (cBioPortal [73, 74]), is positively correlated with lung relapse (Fig. 7a, top), while low expression of Retinoic Acid Receptor Alpha (RARA) is associated with lung relapse (Fig. 7a, bottom). This evidence concerns the gene TFAP2C and breast carcinoma.