For instance, in human primary tumors, high expression of Transcription Factor AP-2 Gamma (TFAP2C), a TF found to be amplified in 6% of primary breast cancers (cBioPortal [73, 74]), is positively correlated with lung relapse (Fig. 7a, top), while low expression of Retinoic Acid Receptor Alpha (RARA) is associated with lung relapse (Fig. 7a, bottom). The gene discussed is TF; the disease is breast cancer.