For instance, levels of reactive oxidative species (ROS) in cancer cells were modulated during chemotherapy, further resulting in MDR regulated by various associated molecules including NADPH oxidases (NOXs), thioredoxin reductases (TrxRs) and nuclear factor erythroid 2-related factor 2 (Nrf2), and so on [24, 25]. The gene discussed is PRDX5; the disease is cancer.