High TFAP2D expression was strongly linked to TMPRSS2:ERG rearrangement and ERG expression: TFAP2D positivity increased from 66.5–73.5% in ERG negative cancers (by IHC or FISH) to 88.2–89.8% in ERG positive cancers (p < 0.0001 each, Fig. 2). This evidence concerns the gene TFAP2D and cancer.