For example, in combination with a strategy using high-throughput sequencing technique, Li S. et al. screened 22 health-strengthening and 25 pathogen-eliminating herbs to identify potential target profiles of 1446 TCM compounds, and several cancer-related pathways of those compounds were identified, such as apoptosis, vascular endothelial growth factor (VEGF) signaling pathway, T cell receptor related pathways, etc. Those herbs have a more significant regulatory role in immune and tumor microenvironment, rather than direct cytotoxic effects on tumors [34]. The gene discussed is VEGFA; the disease is cancer.