Furthermore, Sun et al. (2003) reported that treatment of endometriotic stromal cells with prostaglandin E2 (PGE2) resulted in increased acetylation of histone H3 bound to StAR promoter, with concomitant induction of co-activator CBP/p300, binding of CREB protein, and possible involvement in the pathogenesis of endometriosis [84]. This evidence concerns the gene CREB1 and endometriosis.