APEX1 and endometriosis: Attar et al. in 2010 reported no significant differences between the frequency of genotypes and polymorphic alleles of APE1, XRCC1, XPD, XPG and HOGG1 genes in patients with and without endometriosis, whilst a significant increase in disease frequency would appear to be associated with the XRCC3 Thr/Thr genotype [65].