The activation of GPER triggers diverse transduction pathways including the epidermal growth factor receptor (EGFR), phosphatidylinositol 3-kinase/protein kinase B (PI3K/Akt), and mitogen-activated protein kinases (MAPKs) toward transcriptional and biological responses driving the progression of BC [5,6,7,8]. The gene discussed is AKT1; the disease is breast cancer.