Using cultured CaP cells mimicking the androgen-dependent (AD) and androgen-independent (AI) states, we first reported that ≤ 25 μM resveratrol inhibited cell proliferation and down-regulated the expression of both intracellular and secreted prostate-specific antigen (PSA), a well-documented biomarker for CaP, in AD cells [24,25]. The gene discussed is KLK3; the disease is Alzheimer disease.