Among these factors, older age, Breslow thickness, ulceration, lymph node metastasis, and BRAF V600E positivity were significant prognostic factors on univariate analysis, and older age and the presence of ulceration retained statistical significance (hazard ratio (HR) 1.06, 95% confidence interval (CI) 1.02–1.18, p = 0.0113; and HR 3.82, 95% CI 1.30–11.24, p = 0.0148, respectively) on multivariate analysis. The gene discussed is BRAF; the disease is metastatic malignant neoplasm in the lymph nodes.