Among the 112 acral melanomas, BRAF V600E status was established using Food and Drug Administration (FDA)-approved companion diagnostic kits, the Cobas BRAF V600 Mutation Test (Roche Diagnostics, Mannheim, Germany), or the THxID-BRAF kit (bioMérieux, Lyon, France), in 15 acral melanomas. This evidence concerns the gene BRAF and acral lentiginous melanoma.