Eight weeks of CrPic supplementation was found to repair renal function and reverse renal pathological changes (renal interstitial fibrosis and glomerular sclerosis) in diabetic nephropathy rats by an antioxidative stress mechanism, as well as by inhibiting TGF-β1 and Smad2/3 expressions. This evidence concerns the gene TGFB1 and glomerulosclerosis.