CD8A and neoplasm: Higher mutational load in dMMR-MSI-H tumors correlates with the higher expression of neoantigens on major histocompatibility complex (MHC)-I molecules, thus recruiting more cytotoxic CD8+ T cells for the subsequent immune response and tumor destruction, which follows the notion that frameshift mutations positively correlate with CD8+ T cell infiltration in CRCs [74,75].