IL-6 is overexpressed in CRC [83,84,85], and serves a pro-tumorigenic function through multiple processes, including bolstering angiogenesis through an enhanced expression of VEGF [86], protecting both healthy and malignant intestinal epithelial cells (IECs) from damage-associated molecular patterns (DAMPS), and pathogen-associated molecular patterns (PAMPS), by supporting their growth and survival [87,88,89,90,91], along with bolstering defects in the DNA MMR system [92]. This evidence concerns the gene IL6 and colorectal carcinoma.