FOXO1 and leukemia: Resveratrol, which has been shown to induce autophagy-mediated cell death in leukemia and gastric cancer cells [143,144], showed autophagy inhibition in CCA by promoting deacetylation of FOXO1, impairing FOXO1 binding to Atg7 and blocking autophagy initiation in CCA cells, finally leading to apoptosis [30].