In human non-small-cell lung cancer xenograft, IL-27 down-regulates cancer cell expression of stemness- and epithelial–mesenchymal transition (EMT)-related genes, but also re-educates intratumor myeloid cells to exert antitumor effects [36], which are abolished by myeloablation, thus, suggesting IL-27′s ability to bolster innate immune responses. The gene discussed is IL27; the disease is cancer.