IL30 has also been detected in PC–SLCs isolated from PIN that spontaneously develop in TRAMP mice (hemizygous for the rat probasin-SV40gp6 large T antigen transgene, in a C57BL/6J background [88]), that recapitulate critical features of the human disease [89]. Here, IL27 is linked to prostate intraepithelial neoplasia.