IL21 and asthma: Regarding the control of asthma, the results showed that the mean values of ghrelin, IL-5 and IL-21 among uncontrolled asthmatic children were significantly higher than the corresponding values among controlled-asthmatic children (p = 0.002; p = 0.001; p = 0.001, respectively), while the mean serum IL-4 levels were similar between controlled and uncontrolled asthmatic children (Table 3).