Alzheimer’s disease (AD) is the most common neurodegenerative disorder, neuropathologically characterized by the accumulation of senile plaques and neurofibrillary tangles (mainly composed of amyloid beta (Aβ) peptide and hyperphosphorylated tau protein (p-tau), respectively) [1,2]. Here, MAPT is linked to early-onset autosomal dominant Alzheimer disease.