Liraglutide treatment tended to normalize both estradiol and GLP-1 levels (for brain estradiol levels: Z = −1.358, p = 0.222 for 3xTg-AD + Lira vs. WT mice; Z = −0.548, p = 0.662 for 3xTg-AD + Lira vs. 3xTg-AD mice; Table 2). The gene discussed is GLP1R; the disease is Alzheimer disease.