In line with this, we observed a massive increase in the pro-inflammatory CRP and IL-1β markers in plasma from the 3xTg-AD female mice, whereas the anti-inflammatory IL-10 was only slightly decreased (by 34%) compared to WT female mice (F(2,16) = 2.974; p = 0.08 for plasma CRP levels; for plasma IL-10 levels: Z = −0.857, p = 0.445 for 3xTg-AD vs. WT mice; for plasma IL-1β levels: Z = −2.882, p = 0.002 for 3xTg-AD vs. WT mice; Table 1). Here, CRP is linked to Alzheimer disease.