GCG and Alzheimer disease: Similar to the periphery, levels of brain estradiol and GLP-1 were increased in female mice with early AD-like pathology compared to WT ones (for brain GLP-1 levels: F(2,13) = 2.686; p = 0.106; for brain estradiol levels: Z = −2.191, p = 0.030 for 3xTg-AD vs. WT mice; Table 2).