Despite no significant alterations in active Akt in our conditions, one cannot exclude the involvement of the parallel MAPK/ERK signaling cascade [112], known to mediate its antioxidant, anti-inflammatory, anti-apoptotic and pro-cognition roles [114,115,116,117,118,119,120,121], as well as its benefits in AD symptoms and features [77]. The gene discussed is AKT1; the disease is Alzheimer disease.