Despite no significant alterations in brain insulin levels nor in IR, GLP-1R or activated Akt between cohorts (data not shown), female mice with early AD-like pathology had a massive decrease in brain active PKA kinase that tended to recover with liraglutide (Z = −2.562, p = 0.009 for 3xTg-AD vs. WT mice; Z = −0.548, p = 0.662 for 3xTg-AD + Lira vs. WT mice; Z = −0.913, p = 0.429 for 3xTg-AD + Lira vs. 3xTg-AD mice; Table 2). This evidence concerns the gene INS and Alzheimer disease.