MAPT and Alzheimer disease: Contrary to our previous study in 11-month-old 3xTg-AD male mice that showed increased brain cortical and hippocampal Aβ levels and thigmotaxis, reduced exploratory activity, and deficits in learning and memory [37], in the present study the massive rise in brain cortical Aβ and p-tau content in 11-month-old 3xTg-AD female mice (in line with the Amyloid Cascade Hypothesis—the basis for this mouse model) was accompanied by less pronounced signs of cognitive alterations.