Similar to the well-described neuroinflammation markers in AD patients and animal models [41,42], the brains from 3xTg-AD female mice showed a significant increase in the pro-inflammatory CRP (F(2,11) = 9.337; p = 0.004) and in the anti-inflammatory cytokine IL-10 levels (F(2,14) = 2.447; p = 0.123) compared to WT female mice (Figure 3). This evidence concerns the gene IL10 and Alzheimer disease.