H6PD and Alzheimer disease: Moreover, liraglutide abrogated the decrement in the activity of G6PDH (the limiting enzyme from the oxidative branch of the pentose phosphate pathway) in brains from female mice with early AD-like pathology (Z = −2.309, p = 0.029 for 3xTg-AD vs. WT mice; Z = −2.309, p = 0.029 for 3xTg-AD + Lira vs. WT mice; Z = −2.309, p = 0.029 for 3xTg-AD + Lira vs. 3xTg-AD mice; Figure 5A).