Von Karstedt et al. [17] showed that tumour cell-expressed TRAIL and TRAIL-R2 promote cancer progression, invasion, and metastasis by cancer cell-autonomous activation of Rac1 via the membrane-proximal domain (MPD) of TRAIL-R2 independently of fas-associated death domain (FADD), and according to Hartwig et al. [18] TRAIL is the main immune mechanism supporting cancer growth in colorectal and pancreatic cancer lines, which may also apply to other types of cancers. This evidence concerns the gene TNFRSF10B and familial pancreatic carcinoma.