Furthermore, the combination of nivolumab with radiotherapy in the CheckMate-498 trial (NCT02617589) also failed to significantly prolong the overall survival of patients with newly diagnosed O6-methylguanine-DNA methyltransferase (MGMT)-unmethylated glioblastoma, compared to combined treatment with temozolomide and radiotherapy. The gene discussed is MGMT; the disease is glioblastoma.