We demonstrated that urine osmotic pressure, urine specific gravity, I-FABP, IFN-γ, IL-1β, and TNF-α were reduced in runners provided an 8-week IMP supplementation regimen, indicating that IMP may have the potential to prevent strenuous exercise-induced renal dysfunction, increased intestinal permeability, and inflammation. The gene discussed is IL1B; the disease is Abnormal renal physiology.