The finding that the 37/67 kDa LR may play a key role in Alzheimer’s disease [22,23,26] and that it could act as a receptor mediating Aβ cytotoxicity [24,25], prompted us to verify the effects of a specific 37/67 kDa LR inhibitor on the expression levels and posttranslational modifications of APP, which are known to have a critical role in Aβ generation [14,18]. This evidence concerns the gene APP and early-onset autosomal dominant Alzheimer disease.