Furthermore, a multicenter collaboration from China recently described four patients from three families that presented with PFBC and bi-allelic mutations in JAM2. 15They interestingly show failure of JAM2 to translocate to the plasma membrane in JAM2 transfected mutants of hamster ovary cells, and they propose a cell-to-cell adhesion impairment as the mechanism causing failure of the NVU and consequent brain calcification phenotype. Here, JAM2 is linked to bilateral striopallidodentate calcinosis.