IFNG and Cachexia: The association of IFNγ with cachexia is still not clear, but studies have shown that IFNγ can synergize with TNF‐α to promote muscle wasting.15, 58, 69, 70 IFNγ is also an inhibitor of myosin mRNA in skeletal muscle cells, and it is able to activate ubiquitin gene expression.61, 69, 71