Ghrelin, a peptide that is mainly produced in the stomach and increases appetite, stimulating hunger and food intake, is highly increased in patients with cancer cachexia.3, 13, 132, 133, 134, 135 Ghrelin can also directly affect skeletal muscle cells, inhibiting protein degradation induced by cytokines.3, 136, 137, 138, 139 In this context, increased ghrelin levels are likely to be a compensatory mechanism to buffer cachexia and to represent a mechanism to counter‐balance anorexia.3, 13, 15. This evidence concerns the gene GHRL and Cachexia.