Concerning possible pharmacological treatments for anorexia, a number of specific orexigenics have been developed.195 Megestrol was approved to treat anorexia in patients with AIDS and was also shown to improve weight gain and ameliorate anorexia in children with cancer.195, 221 Cannabinoids also seem to increase appetite by enhancing NPY in the hypothalamus.195 Ghrelin and related substances also have an impact on food intake by anorexic patients.195, 222. The gene discussed is GHRL; the disease is cancer.