They are classified in three maingroups: those that remove the LCR (Locus Controlling Region); others that removepartially or totally the β-cluster genes (∊γδβ0-thalassemia,γδβ0-thalassemia, δβ0-thalassemia); and deletions thatinvolve partial or complete loss of the β-gene, such as, the Asian/Indian 619 bpdeletion of HBB 3’ end, the ≈45 kb Filipino deletion that removesthe entire β-gene, and the recently reported 5’ β-globin gene deletions of 538 bpand 1517 bp (Waye et al., 1994; Patrinos et al., 2004; Shooter et al., 2015; Waye etal., 2017;). Here, PPIB is linked to thalassemia.