NPY2R and diabetes mellitus: In contrast, recent publications suggest NPY does not exert a protective effect in the retina29 and that NPY shows no association at gene level (SNP in NPY2R gene) in patients with diabetes.64 These reports utilize notably different models, addressing different questions but taken together, may suggest that NPY signalling is context‐dependent, with the potential to exert both beneficial neuroprotective and negative effects.