Moreover, bile acids (BAs), via signalling through their dedicated nuclear receptor farnesoid X receptor (FXR; NR1H4) as key regulator of glucose and lipid metabolism, as well as inflammation12, 13, 14, 15, 16, 17 may play an important role in the pathogenesis and treatment of NAFLD/NASH. Here, NR1H4 is linked to metabolic dysfunction-associated steatohepatitis.