Metabolic preconditioning with a hydrophilic BA pool is supposed to protect BSEP KO mice from cholestasis‐induced injury, which is reflected by the absence of hepatic inflammation and fibrosis after bile duct ligation and 3,5‐diethoxycarboncyl‐1,4‐dihydrocollidine (DDC) feeding.29 The gene discussed is ABCB11; the disease is cholestasis.