FAM46C is one of the most commonly mutated genes in MM, with somatic point mutations having been identified in about 10% of newly diagnosed MM cases.9, 10 The vast majority of these mutations are of an inactivating nature, frameshift or non‐sense mutations, which indicates that FAM46C may function as a tumour suppressor.9 In addition, FAM46C is located in cytoband 1p12, which is known to be deleted in approximately 20% of MM patients. Here, TENT5C is linked to Miyoshi myopathy.