3‐M syndrome has been causally related to CUL7, OBSL1, and CCDC8 variants, but the underlying mechanisms remain largely unknown.1, 6, 17 Huber et al reported for the first time that CUL7 variants are convincingly associated with 3‐M syndrome in 2005. Here, CCDC8 is linked to multiple congenital anomalies-hypotonia-seizures syndrome 3.