Consistent with this, SMAD3, which plays an essential role in TGFβ signalling, has been shown to link shape information to transcription in breast cancer cells (Sailem & Bakal, 2017), while WNT signalling can be linked to cell microenvironment via the differential localisation of its downstream effector β‐catenin. This evidence concerns the gene TGFB1 and breast cancer.