TGFB1 and colorectal cancer: For example, the roles of genes within the context of development, such as mesoderm development (MSD), which involves the coordination of cell migration, cell adhesion and cytoskeletal organisation through TGFβ and WNT signalling, are often deregulated within the context of colorectal cancer (Klinowska et al, 1994; McMahon et al, 2010; Kiecker et al, 2016).