It has been shown that there is decrease in the expression of SRC-like adaptor protein (SLAP) [84] and liver kinase B1 (LKB1) [85] in ICC tissues and cells along with a decrease in fructose-1,6-bisphosphatase 1 (FBP1) in CCA cells [86]. This evidence concerns the gene FBP1 and intrahepatic cholangiocarcinoma.