According to recent studies, DEPDC5 variants are associated with a spectrum of focal epilepsy phenotypes, ranging from nonlesional familial focal epilepsies to malformation‐associated focal epileptic syndromes.15, 20 Also, variants in this gene may be associated with a higher rate of refractory epilepsies, as suggested by Baulac and colleagues,20 who reported that the majority of patients with refractory epilepsy presented with DEPDC5 variants. This evidence concerns the gene DEPDC5 and focal epilepsy.