We previously reported that the serum concentration of h-S100A8/A9 in patients with IBD was significantly higher than that in healthy volunteers (HVs), and that a positive correlation between the level of circulating h-S100A8/A9 in the patients and the disease activity index (DAI) score was found (Okada et al., 2019). The gene discussed is S100A8; the disease is inflammatory bowel disease.