Desmopressin (DDAVP) is used in cases where there is a positive response to the test, in patients with type 1 VWD with basic levels of FVIII and VWF >10 U/dL [7, 8], while in other VWD subtypes the response to DDAVP is significantly reduced. This evidence concerns the gene F8 and von Willebrand disease (hereditary or acquired).