Gene-gene interactions of rs1800469 (TGFB1), rs2070729 (IRF1), rs5275 (PTGS2), rs4648308 (PTGS2), rs2166975 (TGFA), rs5029748 (IKBKB) and the risk of depression occurrence. The gene discussed is TGFB1; the disease is depressive symptom measurement.