In reference to effect of combined genotypes, it was found that G/G-T/T genotypes of g.70677994G>A (rs2166975)—TGFA and g.186640617C>T (rs4648308)—PTGS2 was associated with decreased risk of depression occurrence, while A/G-C/T genotypes increased this risk. The gene discussed is PTGS2; the disease is major depressive disorder.