Moreover, carriers of A/C-A/G combined genotypes of g.132484229C>A (rs2070729)—IRF1 and g.186643058A>G (rs5275)—PTGS, A/C-G/T of g.132484229C>A (rs2070729)—IRF1 and g.42140549G>T (rs5029748)—IKBKB as well as G/T-C/T genotypes of g.42140549G>T (rs5029748)—IKBKB and g.186640617C>T (rs4648308)—PTGS2 had a greater risk of MDD appearance. This evidence concerns the gene PTGS2 and major depressive disorder.