Using the most stringent MOMENT model, we identified 1 DMP between ALS cases and controls, which is annotated to CXXC5 on chromosome 5 (cg04104695, pMOA = 2.7 × 10−7, pMOMENT = 2.1 × 10−7, decreased blood DNA methylation associated with ALS). The gene discussed is CXXC5; the disease is amyotrophic lateral sclerosis.