Furthermore, we searched for hints of any altered immunogenicity of these proteins in POAG and validated an increase in AAbs against of paraneoplastic antigen Ma2 (PNMA2), threonine‐tRNA ligase (TARS) and complement component 1 Q subcomponent‐binding protein (C1QBP) by antigen microarray. This evidence concerns the gene C1QBP and open-angle glaucoma.