As shown in Figures 5A, B, Ad-26b-5p, Ad-204-5p, and Ad-497-3p infections significantly decreased the IGF-1 induced expression of LC3 II in cardiomyocyte hypertrophy, as reflected by reduced fluorescence (P < 0.01, P < 0.05, P < 0.01, respectively). The gene discussed is IGF1; the disease is infection.