Previous studies also demonstrated that ULK1 and LC3B were activated during cardiac hypertrophy, and Beclin1 mediated autophagy was also enhanced during right ventricular remodeling (Huang et al., 2015; Deng et al., 2017; Zhang et al., 2019), supporting our finding that ULK1, LC3B, and Beclin1 were up-regulated in physiological LVH. Here, MAP1LC3B is linked to cardiac hypertrophy.