METTL3 and acute myeloid leukemia: It is known that methyladenosine (m6A) is a reversible nucleotide modification catalyzed by the METTL3/METTL14 methyltransferase complex4, that is involved in various normal biological processes, such as stem cell self-renewal and differentiation (Deng et al., 2018), as well as in AML pathogenesis (Vu et al., 2017; Barbieri et al., 2017).