As well, conventional NGS approaches show limitations for the detection of longer FLT3 internal tandem duplications (ITDs) (Schranz et al., 2018) whose characterization is crucial in cytogenetically normal AML without NPM1 mutation, where FLT3-ITDs length was recently associated to a worse outcome (Chen et al., 2019). The gene discussed is FLT3; the disease is acute myeloid leukemia.