BTK and B-cell chronic lymphocytic leukemia: For example, it is well known that altered p53 function, due to a 17p deletion (del(17p)) and/or TP53 gene mutation, is associated with poor prognosis in chronic lymphocytic leukemia (CLL) patients, who are candidates for Bruton tyrosine kinase inhibitor treatment (Malcikova et al., 2018).