TP53 and B-cell chronic lymphocytic leukemia: TP53 NS with MinION was initially performed as a single test (Minervini et al., 2016), then as part of a gene panel including the most frequently mutated genes in CLL (Orsini et al., 2018), and was finally included in a screening assay encompassing TP53 mutational analysis, del(17p) detection, and IgHV mutational status evaluation (Burns et al., ).